Curriculum Vitae

 

Name:

Amina Kariminia Ph.D.

Address:

Immunology Dept., Pasteur Institute of Iran (IPI), No. 69, Pasteur Ave., Tehran 1316943551, Iran

Tel:

(+98-21) 6695 3311-20   ext. 2116

Fax:

 (+98-21) 6696 8857

E- mail:

 akariminia@pasteur.ac.ir

Nationality:

Iranian

Date of Birth:

 30 Dec 1960             

Marital Status:

 Married

Position:

 Associate Professor 

 

Educations:

Ph.D. (2000): Clinical Immunology, Tehran University of Medical Sciences

Title of the Ph.D. Thesis: Investigation of cytokine productions by peripheral blood mononuclear cells of healthy individuals in response to live procyclic, metacyclic and amastigotes forms of Leishmania major
 

M.Sc. (1991): Clinical Immunology, Tehran University of Medical Sciences

Title of the M.Sc. Thesis: Induction of partial protection against experimental cutaneous leishmaniasis in BALB/c mice immunized by fractionated Leishmania major antigens
 

B.Sc. (1986): Cellular Biology, Tehran University

 

Work Experience:

  1. Since 2000-present: worked at Immunology Department of Pasteur Institute of Iran as assistant professor, teaching immunology tp Ph. D. and MSc students, supervising thesis, performing flow cytometry and PCR, RT-PCR, cloning.

  2. Since 1991-2000: worked at Immunology Department of Pasteur Institute of Iran as research assistant performing cell culture, cytokine assay, protein purification and immuno-chemistry techniques.

  3. Since 1986-1991: worked at Immunology Department of Pasteur Institute of Iran as laboratory technician performing all serology tests.

 

Supervising:

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One M.Sc. Thesis in Cellular and Molecular Biology 2002 (Supervisor Prof)

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Four M. Sc. Thesis in Biochemistry (Consultant Prof.)

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Two Ph. D. Thesis in Biochemistry (Consultant Prof.)

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One Ph. D. Thesis in Clinical Immunology (Consultant Prof.)


 

Grants:  

  1. Study of IFN-gR expression and signaling during experimental cutaneous leishmaniasis in murine model.  The grant received financial support from Institute Pasteur of Iran. (Finished).

  2. Study of the effect of Thalidomide on experimental cutaneous leishmaniasis. The grant received financial support from Institute Pasteur of Iran. (Finished).

  3. Assessment of IFN-gR a &b chain expression and IFN-gR signaling in human VL (on going).

  4. Cloning expression of K39 antigen of L. Infantum and setting up Elisa kit  for diagnosis of human visceral leishmaniasis (financial support from Biotechnology research net, on going).

  5. Assessment of IFN-gR a &b chain mRNA during experimental cutaneous leishmaniasis in murine model (financial support from TWAS, Finished). 

 

Fellowship:

  1. Worked in Clinical Science Department, London: School of Hygiene and Tropical Medicine from 1993 till 1994 under supervision of Prof. John Rayens studying the potential role of Serum Amyloid A in induction of Alziemer's Disease, trained for protein purification techniques including column chromatography, HPLC, affinity chromatography, TLC, RIA, cell culture and cytokine bioassay for IL-6, TNF, and cytokine measurements for IL-1 and IL-1RA by lab-made ELISA.

  2. Worked in the unite of Immunologie des Leishmanoises, Institut Pasteur de la Guyane Française, from June 2002 till June 2003, under Dr Pascal Launois supervision studying the preferential expression of TCR V beta gene family in biopsies of cutaneous leishmaniasis patients due to L. guyanensis compared to the same gene expression of antigen stimulated PBMCs. Trained for molecular biology techniques.

 

Foreign Language Certificates: 

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First certificate in English, 1993, London
IELT , 1993, London
 

Publications: 

International:  

  1. Gholamreza Kavoosi, Sussan K. Ardestani, Amina Kariminia, Mohsen Abolhassani, Salvatore J. Turco (2006) Leishmania major: Reactive Oxygen species and interferon gamma induction by soluble lipophosphoglycan of stationary phase promastigotes. Experimental Parasitology, April 2006.

  2. Gholamreza Kavoosi, Sussan K. Ardestani,  Amina Kariminia, Mohsen Abolhassani and Turco S.J (2006) Leishmania major reactive oxygen species and interferon gamma induction by soluble lipphosphoglycan of stationary phase promostigotes.  Experimental Parasitology (Accepted for publication, April 2006)

  3. Alireza Rafiei, Sussan K. Ardestani, Amina Kariminia, Abdolhosein Keyhani, Mino Mohraz, Aref Amirkhani  (2006) Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease. Journal of Infection, (In Press)

  4. Mohammad Reza Mohammadi, Majid Zeinali, Sussan K. Ardestani and Amina Kariminia (2006) Identification of novel Leishmania major antigens that elicit IgG2a response in resistant and susceptible mice. The Korean Journal of Parasitology in Press 2006, Vol. 44, No. 1. (In press).

  5. Ghassem Solgi, Amina Kariminia, Khossro Abdi, Majid Darabi and Behnaz Ghareghozloo (2006) Effects of combined therapy with thalidomide and glucantime on leishmaniasis induced by Leishmania major in BALB/c mice. The Korean Journal of Parasitology, (Iin Press).

  6. Gholamreza Kavoosi, Sussan K. Ardestani, Zahra Tavakoli and Amina Kariminia (2006) Production of nitric oxide in murine macrophages induced by lipophosphoglycan of Leishmania major. The Korean Journal of Parasitology, (In Press).

  7. Transforming Growth Factor beta1 Production by CD4+ CD25+Regulatory T Cells in Peripheral Blood Mononuclear Cells from Healthy Subjects Stimulated with Leishmania guyanensis (2005) A. Kariminia, E. Bourreau, H. Pascalis, P. Couppie, D. Sainte-Marie, F. Tacchini-Cottier and P. Launois. Infection and Immunity, Vol. 73, No. 9.

  8.  Farajnia S, Mahboodi F, Ajdari S, Reiner NE, Kariminia A, and Alimohammadian MH. (2005) Mononuclear cells from patients recovered from cutaneous leishmaniasis respond to Leishmania major amastigote class I nuclease with a predominant Th1-like response. Cli Exp Immunology, 139: 498-505.

  9. Long-term immune and cytogenetic effects of high level natural radiation on Ramsar inhabitants in Iran (2004) Ghiassi-Nejad M, Zakeri F, Assaei RG, Kariminia A.  J Environ Radioact. 74 (1-3): 107-16.

  10.  Increased production of IFN-g by LACK-reactive CD4+ T cells among human blood mononuclear cells: an early marker of exposure to Leishmania? (2003) Eliane Bourreau, Hervé Pascalis, Ghislaine Prévot, Amina Kariminia, Nathalie Jolly, Genevieve Milon, Pierre Buffet, Rémy Michel, Jean-Baptiste Meynard, Jean-Paul Boutin, Dominique Aschimoff, and Pascal Launois. Scandinavian J. Immunology, Vol. 58: 201-210.

  11. Th1 cell development towards Cysteine Proteinase A and B in Localized Cutaneous Leishmaniasis due to L. guyanensis (2003) Hervé Pascalis, Anne Lavergne, Eliane Burreau, Ghislaine Prévot-Linguet, Amina Kariminia, Roger Pradinaud, Sima Rafati, and Pascal Launois.  Infection and Immunity, 71 (5): 2924-6.

  12. Th2 responses predominates during early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses (2003) Eliane Bourreau, Jacques Gardon, Roger Pradinaud, Hervé Pascalis, Ghislaine Prévot-Linguet, Amina Kariminia and Launois Pascal,  Infection and Immunity, 71 (4): 2244-46.

  13. Expansion of gamma-delta T Cells in Patients Infected with Cutaneous Leishmaniasis with and without Glucantime Therapy. (2002) Darabi H, Abolhassani M, Kariminia A, Alimohammadian MH.  Braz J Infect Dis, 6 (5): 258-62.

  14. Recombinant cystein proteinase-based vaccines against Leishmania major in BALB/c mice: The partial protection relies on IFN-g producing CD8+T lymphocytes activation (2002) Sima Rafati, Amina Kariminia, Shiva Taheri, Mai Labbatard. Vaccine 20: 2439-47.

  15. Induction of interleukin-10 but not interleukin-12 by Brucella lipopolysaccharide (2002) Amina Kariminia, Gholamreza Kavoossy, Esmaeil Zowghi , and  Sussan K. Ardestani.  Comparative Immunology, Microbiology and Infectious Disease, Vol. 25, 2: 85-94.

 

National Journals in English:

  1. Interferon gamma unresponsivenes due to down-regulation of  IFNγR expression in experimental cutanous leishmaniasis (April 2006) Amina Kariminia, Susan K. Ardestani, Houri Sepehry and Haideh Darabi.  Iranian Biomedical journal 10 (2): 105-109.

  2. The Effect of Vitamin E on Splenocytes Apoptosis of Gamma-Irradiated BALB/c Mice (June 2005) Bahman Maroufi, Kaboudanian Sussan Ardestani, Amina Kariminia, and Hussain Naderimanesh. Iranian Journal of Allergy, Asthma and Immunology, Vol. 4, No. 2, p. 77-82.

  3. Characterisation of Leishmania species and L. major strains in different endemic areas of cutaneous leishmaniasis in Iran (2003) Mahnaz Tashakori, Soheila Ajdary, Amina Kariminia, Fereidoun Mahboudi, and Mohammad hossein Alimohammadian.  Iranian Biomedical Journal, 7 (2): 43-50.

  4. Restorative effect of Vitamin E supplementation on hepatic lipid peroxidation and lipid profile changes induced by sub-lethal radiation in Balb/c mice (January 2003) Sussan K. Ardestani, Mehrali M. Janlow, Efaht Souri, and Amina Kariminia. Iranian Biomedical Journal, 6 (1): 37-42.

  5. Down-regulation of T cell function by heat shock-induced excretory factor of Leishmania major (2002) Amina Kariminia, Haideh Darabi, Sussan K. Ardestani,  Behnaz Gharegozloo. Iranian Journal of Medical Science, 27 (2): 70-74.

  6. Adjuvant effect of Leishmania major promastigotes on the immune response of mice to ovalbumin (2002) Mohammad Hossein Alimohammadian, Haideh darabi, Amina Kariminia, Denis Rivier, Philippe Bovay, Jacque Mauel, Soheila Ajdary, and Arsalan Kharazmi. Iranian Biomedical Journal, 6 (4): 123-128.

  7. Induction of Th1 response is more potent by live logarithmic phase promastigotes of L. major than stationary phase parasites (January 2001) Amina Kariminia, Haideh Darabi, Abdulhossein Keyhani and Mohammad Hossein Alimohammadian. Iranian Biomedical Journal, 5 (1): 9-14.

  8. Study of nitric oxide production by murine peritoneal macrophages induced by Brucella lipopolysaccharide (2000) Gholamreza Kavoosi, Sussan K. Ardestani and Amina Kariminia. Acta Medica Iranica, 39 (3): 136-140.

  9. Live logarithmic phase promastigotes of L. major induce high level of IFN-g but low level of IL-10 in whole blood culture of healthy individuals (2000) Amina Kariminia, Sudabeh Asslanian, Abdulhossein Keyhani, and Mohammad Hossein Alimohammadian.  Acta Medica Iranica, 38 (3): 168-73.

  10.  Restorative effect of vitamin E on some immunological parameters of sub-lethal gamma irradiated BALB/c mice (January 2000) S. K. Ardestani, M. Amani, A. Kariminia.  Iranian Biomedical Journal, 4 (1): 51-55. 

 

National Journals in Persian:

  1.  كاهش توليد اينترفرون گاما با افزايش توليد اينترلوكين 12 در بيماران مبتلا به بروسلوز مزمن, عليرضا رفيعي, آمينا كريمي نيا, ابواقاسم عجمي, سوسن كبودانيان اردستاني. مجله علمي پژوهشي دانشگاه علوم پزشكي مازندران سال چهاردهم شماره 42 1383 صفحه 11 تا 19.   

  2.  اثر حفاضتی رانیتیدین بر پاسخ اختصاصی سیستم ایمنی موشهای پرتو دیده ، سوسن کبودانیان اردستانی، مجتبی امانی و آمینا کریمی نیا، مجله علوم دانشگاه تهران، جلد سیام، 1383 شماره 3 صفحات 507 الی515 .

  3.  جدا سازي و شناسايي آنتي ژنهاي بروسلرژنْ,  سوسن كبودانيان اردستاني, مهدي زين الدديني , آمينا كريمي نيا , اسماعيل ذوقي. مجله بيماري هاي عفوني و گرمسيري سال هشتم 1382 شماره 23 صفحه14 تا 19.

  4.  ارزيابي تست سرولوژيك دات-اليزا در تشخيص بيماري بروسلوز در بيمارستان امام خميني در سال 1379, دكتر مينو محرز, دكتر آمينا كريمي نيا, دكتر عبدالفتاح صراف نژاد, دكتر زهرا المعي. . مجله بيماري هاي عفوني و گرمسيري سال هشتم 1382 شماره 23 صفحه 10 تا 13.

  5. شناسایی بروز سیتوکاینهای داخل سلولی در خون کامل افراد سالم و بیماران مبتلا به بروسلوزیس .علیرضا رفیعی، عبدلحسین  کیهانی، آمینا کریمی نیا، سوسن کبودانیان اردستانی، مینو محرز، عارف امیر خانی.  مجله دانشکده پزشکی دانشگاه علوم پزشکی تهران، سال 1362، شماره 5، صفحات 363 الی 371.

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